Introduction

The market for therapeutic antibodies has dramatically expanded over the past decades since their first approval in 1986.

Antibodies, which are proteins, form their structure and exert their activity through a complex series of non-covalent bonds and may lose their activity due to various external stimuli.

Therefore, the evaluation of structural stability is extremely important in the development and formulation of candidate antibodies.

Thermodynamic stability of antibodies is generally evaluated by DSC (differential scanning calorimetry) and circular dichroism (CD) spectroscopy.

Circular Dichroism spectroscopy is an easy and rapid method for obtaining information on the secondary and tertiary structure of proteins in solution and can be used to directly evaluate the protein structural change caused by heat.

Recently, Micsonai et al. developed the BeStSel algorithm that can accurately estimate the secondary structure composition from the CD spectrum by taking into account the parallel-antiparallel orientation of the β-strands and the twist of the antiparallel β-sheets.

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BeStSel has the following features:

High estimation accuracy for a wide range of proteins, including β-structure-rich-proteins such as antibodies

Providing eight types of secondary structure information

A capability to predict the protein fold following the CATH classification

An open web server

While many academic researchers use the BeStSel web server, researchers in biopharma who need to work in a GxP environment have not been able to benefit from BeStSel.

To make BeStSel accessible to biopharma, JASCO developed Spectra Manager™ Ver.2.5 CFR BeStSel as an add-in software for Spectra Manager™, a control and analysis platform for CD spectrometers, which is compatible with GxP.

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Real-time styling sessions where she shares her thought process on pairing outfits for specific events.

While many influencers chase logos, Roohi’s style content prioritizes texture: raw silk, crushed velvet, cable-knit wool, and patent leather. She teaches her audience how to mix matte and gloss finishes without clashing.

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Were you looking for a specific from her, or information on her career as a model ?

No long-form article on a public figure would be complete without addressing criticism. Some traditionalist fashion editors have accused the of "aesthetic violence"—mixing high jewelry with streetwear. Others claim her "de-influencing" segments inadvertently harm small businesses. Real-time styling sessions where she shares her thought

If there is one takeaway from the Roohi Roy content ecosystem, it is that fashion should be accessible and fun. Here are a few practical takeaways curated from the Roohi universe:

: Championing regional craftsmanship, heavy embroidery, and artisanal work tailored for festive or wedding-ready ensembles. Contemporary Western and Casual Streetwear Roy balances her heavy festive outfits with fresh,

: Historical reports from 2014 detail her detention following a hotel raid in Hyderabad, though all charges were later withdrawn, and she issued a formal letter to clarify the events.

A slower, cinematic vlog where she discusses the psychology of clothing. How does a blazer change your posture? Why do we hold onto clothes from ex-partners? This narrative depth elevates her from influencer to creator.